PRODUCTION OF GANODERMA LUCIDUM EXTRACT LOADED GELATIN-SODIUM ALGINATE MICROSPHERES, INVESTIGATION OF RELEASE KINETICS AT DIFFERENT pH VALUES AND EVALUATION OF KINETIC MODELS

In this study, pH sensitive microsphere polymeric drug carriers were produced by using biodegradable natural gelatin and sodium alginate polymers. Microspheres loaded with prepared Ganoderma lucidum extract that is a medicinal mushroom has the potential to be used in several diseases’ treatment. Extract release kinetics of microspheres examined spectrophotometric method an UV spectrometer. Buffer solutions different values as medium for examination microspheres. The was presented terms percent cumulative (CR%) defined percentage ratio instantaneous amount released at certain time incubation initial loadings. As result, it seen accelerated increased fastest observed 7. kinetic models examined. fitted Higuchi model 1.3, 5.0 6.0 first-order 3.0 7.0.